Macrolide Resistance–associated 23S rRNA Mutation inMycoplasma genitalium, Japan
نویسندگان
چکیده
منابع مشابه
Macrolide Resistance–associated 23S rRNA Mutation in Mycoplasma genitalium, Japan
because we included samples from children hospitalized with or without respiratory disease. BLAST search (www.ncbi.nlm. nih.gov/blast/Blast.cgi) and phylogenetic analysis of amplicons from PCR and nested PCR indicated that samples were positive for HKU1 genotype B (samples BRA169, BRA90, and BRA99) or HKU1 genotype A (samples BRA09, BRA37, and BRA104). The sequences obtained in this study have ...
متن کاملEmergence of macrolide-resistant Mycoplasma pneumoniae with a 23S rRNA gene mutation.
A total of 195 Mycoplasma pneumoniae strains were isolated from 2,462 clinical specimens collected between April 2002 and March 2004 from pediatric outpatients with respiratory tract infections. Susceptibilities to six macrolide antibiotics (ML), telithromycin, minocycline, levofloxacin, and sitafloxacin were determined by the microdilution method using PPLO broth. A total of 183 M. pneumoniae ...
متن کاملMutation in 23S rRNA associated with macrolide resistance in Neisseria gonorrhoeae.
Fifty-six azithromycin-resistant (MICs, 2.0 to 4.0 micro g/ml) Neisseria gonorrhoeae strains with cross-resistance to erythromycin (MICs, 2.0 to 64.0 micro g/ml), isolated in Canada between 1997 and 1999, were characterized, and their mechanisms of azithromycin resistance were determined. Most (58.9%) of them belonged to auxotype-serotype class NR/IB-03, with a 2.6-mDa plasmid. Based on resista...
متن کاملRemarkable increase in fluoroquinolone-resistant Mycoplasma genitalium in Japan.
OBJECTIVES We determined the prevalence of macrolide and fluoroquinolone resistance-associated mutations in Mycoplasma genitalium DNA specimens from men with non-gonococcal urethritis (NGU) and analysed their effects on antibiotic treatments of M. genitalium infections. METHODS In this retrospective study, we examined antibiotic resistance-associated mutations in the 23S rRNA, gyrA and parC g...
متن کامل23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.
The 23S rRNA A2058G alteration mediates macrolide, lincosamide, and streptogramin B resistance in the bacterial domain and determines the selectivity of macrolide antibiotics for eubacterial ribosomes, as opposed to eukaryotic ribosomes. However, this mutation is associated with a disparate resistance phenotype: It confers high-level resistance to ketolides in mycobacteria but only marginally a...
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ژورنال
عنوان ژورنال: Emerging Infectious Diseases
سال: 2011
ISSN: 1080-6040,1080-6059
DOI: 10.3201/eid1706.101055